Evidence for the Existence of a Multidrug Efflux Transporter Distinct from NorA in Staphylococcus aureus

A Staphylococcus aureus norA disruption mutant was created by allelic replacement. Exposure of this mutant to norfloxacin produced SA K1748, a derivative with raised fluoroquinolone MICs, found to be the result of a grlA mutation, and raised organic cation MICs. Ethidium and enoxacin uptake was iden...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kaatz, Glenn W., Seo, Susan M., O'Brien, Louise, Wahiduzzaman, Mohammad, Foster, Timothy J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89884/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10770791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.5.1404-1406.2000
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