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Toward Antiviral Strategies That Resist Viral Escape

We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-targe...

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Detalles Bibliográficos
Main Authors: Endy, Drew, Yin, John
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC89823/
https://ncbi.nlm.nih.gov/pubmed/10722522
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