Streptococcus gordonii Strains Resistant to Fluorodeoxyuridine Contain Mutations in the Thymidine Kinase Gene and Are Deficient in Thymidine Kinase Activity

Mutants of Streptococcus gordonii resistant to 5-fluorodeoxyuridine (FUdR(r)) were isolated. Each strain contained a point mutation resulting in the premature termination of the thymidine kinase (TK) open reading frame (tdk). In vitro translation of the mutant tdk coding regions resulted in synthesi...

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Julkaisussa:	Antimicrob Agents Chemother
Päätekijät:	Franke, C. A., Bolman, T. M., Ottum, S. A., Jones, K. F., Hruby, D. E.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 2000
Aiheet:	Mechanisms of Resistance
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681361/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.787-789.2000
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