A Double-Blind Placebo-Controlled Study of an Infusion of Lexipafant (Platelet-Activating Factor Receptor Antagonist) in Patients with Severe Sepsis

Platelet-activating factor (PAF) is a potent endogenous proinflammatory mediator implicated in the pathogenesis of septic shock. A double-blind randomized placebo-controlled trial of an intravenous PAF receptor antagonist (lexipafant) was conducted with 131 adult Thai patients with suspected severe...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Suputtamongkol, Yupin, Intaranongpai, Sunanta, Smith, Michael D., Angus, Brian, Chaowagul, Wipada, Permpikul, Chairat, Simpson, Julie A., Leelarasamee, Amorn, Curtis, Lloyd, White, Nicholas J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Clinical Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681340/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.693-696.2000
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