Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori

Mutations in the rdxA gene have been associated with the acquisition of resistance to metronidazole in Helicobacter pylori. This gene encodes an NADPH nitroreductase whose expression is necessary for intracellular activation of the drug. We wished to examine whether mutations in rdxA were present in...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Tankovic, Jacques, Lamarque, Dominique, Delchier, Jean-Charles, Soussy, Claude-James, Labigne, Agnes, Jenks, Peter J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.608-613.2000
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