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Pharmacokinetics and Safety of Ascending Single Doses of DZ-2640, a New Oral Carbapenem Antibiotic, Administered to Healthy Japanese Subjects

DZ-2640 is the ester-type oral carbapenem prodrug of an active parent compound, DU-6681. The pharmacokinetics and safety of DU-6681 were investigated in six studies after oral administration of a single dose of DZ-2640 to healthy male Japanese volunteers at doses of 25, 50, 100, 200, and 400 mg (as...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Tanaka, Makoto, Kato, Kinuyo, Hakusui, Hideo, Murakami, Yoichi, Sato, Kenichi, Ito, Yasushi, Kawamoto, Keiji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89729/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681321/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.578-582.2000
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