High-Level Expression of Chromosomally Encoded SHV-1 β-Lactamase and an Outer Membrane Protein Change Confer Resistance to Ceftazidime and Piperacillin- Tazobactam in a Clinical Isolate of Klebsiella pneumoniae

We describe Klebsiella pneumoniae 15571, a clinical isolate resistant to ceftazidime MIC = 32 μg/ml) and piperacillin-tazobactam (MICs = 1,024 and 128 μg/ml). K. pneumoniae 15571 expresses a single β-lactamase with a pI of 7.6. However, when cloned in a high-copy-number vector in Escherichia coli, t...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Rice, Louis B., Carias, Lenore L., Hujer, Andrea M., Bonafede, Mary, Hutton, Rebecca, Hoyen, Claudia, Bonomo, Robert A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639363/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.2.362-367.2000
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