Engineering the Specificity of Antibacterial Fluoroquinolones: Benzenesulfonamide Modifications at C-7 of Ciprofloxacin Change Its Primary Target in Streptococcus pneumoniae from Topoisomerase IV to Gyrase

We have examined the antipneumococcal mechanisms of a series of novel fluoroquinolones that are identical to ciprofloxacin except for the addition of a benzenesulfonylamido group to the C-7 piperazinyl ring. A number of these derivatives displayed enhanced activity against Streptococcus pneumoniae s...

Full description

Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Alovero, Fabiana L., Pan, Xiao-Su, Morris, Julia E., Manzo, Ruben H., Fisher, L. Mark
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Mechanisms of Resistance
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89678/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.2.320-325.2000
Tags:	Add Tag No Tags, Be the first to tag this record!