Biochemical Characterization of Novel Tetrahydrofuranyl 1β-Methylcarbapenems: Stability to Hydrolysis by Renal Dehydropeptidases and Bacterial β-Lactamases, Binding to Penicillin Binding Proteins, and Permeability Properties

The biochemical properties of tetrahydrofuranyl (THF) carbapenems, carbapenems with THF substituents, were evaluated with respect to enzyme stability, binding to penicillin-binding proteins (PBPs), and penetration into gram-negative organisms. THF carbapenems showed increased stability to hog renal...

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Bibliographic Details
Main Authors: Yang, Youjun, Testa, Raymond T., Bhachech, Niraja, Rasmussen, Beth A., Bush, Karen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89585/
https://ncbi.nlm.nih.gov/pubmed/10582880
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