Molecular Characterization of rpoB Mutations Conferring Cross-Resistance to Rifamycins on Methicillin-Resistant Staphylococcus aureus

Mutations of the rpoB gene conferring resistance to rifampin were analyzed in 40 methicillin-resistant Staphylococcus aureus isolates obtained from six countries. Interestingly, the majority of clinical isolates showed multiple mutations within rpoB. The amino acid substitution 481His→Asn was the mo...

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Main Authors: Wichelhaus, Thomas A., Schäfer, Volker, Brade, Volker, Böddinghaus, Boris
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89569/
https://ncbi.nlm.nih.gov/pubmed/10543773
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