Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore

Genotypic analysis of resistance to isoniazid (INH) in Mycobacterium tuberculosis is complex due to the various genes potentially involved. Mutations in ketoacyl acyl carrier protein synthase (encoded by kasA) were present in 16 of 160 (10%) INH-resistant isolates (R121K [n = 1], G269S [n = 3], G312...

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Autors principals: Lee, Ann S. G., Lim, Irene H. K., Tang, Lynn L. H., Telenti, Amalio, Wong, Sin Yew
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89423/
https://ncbi.nlm.nih.gov/pubmed/10428945
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