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In Vitro and In Vivo Activities of Syn2190, a Novel β-Lactamase Inhibitor

Syn2190, a monobactam derivative containing 1,5-dihydroxy-4-pyridone as the C-3 side chain, is a potent inhibitor of group 1 β-lactamase. The concentrations of inhibitor needed to reduce the initial rate of hydrolysis of substrate by 50% for Syn2190 against these enzymes were in the range of 0.002 t...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Nishida, Kouichi, Kunugita, Chieko, Uji, Tatsuya, Higashitani, Fusahiro, Hyodo, Akio, Unemi, Norio, Maiti, Samarendra N., Phillips, Oludotun A., Spevak, Paul, Atchison, Kevin P., Salama, Sameeh M., Atwal, Harninder, Micetich, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89387/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428909/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1895
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