Construction and Characterization of Mutants of the TEM-1 β-Lactamase Containing Amino Acid Substitutions Associated with both Extended-Spectrum Resistance and Resistance to β-Lactamase Inhibitors

Extended-spectrum TEM β-lactamases (ESBLs) do not usually confer resistance to β-lactamase inhibitors such as clavulanate or tazobactam. To investigate the compatibility of the two phenotypes we used site-directed mutagenesis of the bla(TEM-1) gene to introduce into the TEM-1 β-lactamase amino acid...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Stapleton, Paul D., Shannon, Kevin P., French, Gary L.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Mechanisms of Resistance
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89385/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10428907/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.8.1881
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