Improvement of In Vitro and In Vivo Antileishmanial Activities of 2′,6′-Dihydroxy-4′-Methoxychalcone by Entrapment in Poly(d,l-Lactide) Nanoparticles

The inhibition of intracellular Leishmania amazonensis growth by 2′,6′-dihydroxy-4′-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, a...

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Autors principals: Torres-Santos, Eduardo Caio, Rodrigues, José M., Moreira, Davyson L., Kaplan, Maria Auxiliadora C., Rossi-Bergmann, Bartira
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89364/
https://ncbi.nlm.nih.gov/pubmed/10390243
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