Impact of gyrA and parC Mutations on Quinolone Resistance, Doubling Time, and Supercoiling Degree of Escherichia coli

Isogenic mutants derived from quinolone-susceptible isolate WT by introducing gyrA (S83L, D87G) and parC (S80I, E84K) mutations associated with quinolone resistance were characterized with respect to quinolone resistance, growth rate, and degree of global supercoiling. The latter was determined by u...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Bagel, Simone, Hüllen, Volker, Wiedemann, Bernd, Heisig, Peter
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1999
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10103193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.4.868
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