Safety and Pharmacokinetics of Abacavir (1592U89) following Oral Administration of Escalating Single Doses in Human Immunodeficiency Virus Type 1-Infected Adults

Abacavir (1592U89) is a nucleoside analog reverse transcriptase inhibitor that has been demonstrated to have selective activity against human immunodeficiency virus (HIV) in vitro and favorable safety profiles in mice and monkeys. A phase I study was conducted to evaluate the safety and pharmacokine...

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Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Kumar, Princy N., Sweet, Donna E., McDowell, James A., Symonds, William, Lou, Yu, Hetherington, Seth, LaFon, Stephen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1999
Предметы:	Pharmacology
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.3.603
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