8-Aminoquinolines Active against Blood Stage Plasmodium falciparum In Vitro Inhibit Hematin Polymerization

From the Walter Reed Army Institute of Research (WRAIR) inventory, thirteen 8-aminoquinoline analogs of primaquine were selected for screening against a panel of seven Plasmodium falciparum clones and isolates. Six of the 13 8-aminoquinolines had average 50% inhibitory concentrations between 50 and...

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Main Authors: Vennerstrom, Jonathan L., Nuzum, Edwin O., Miller, Robert E., Dorn, Arnulf, Gerena, Lucia, Dande, Prasad A., Ellis, William Y., Ridley, Robert G., Milhous, Wilbur K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC89166/
https://ncbi.nlm.nih.gov/pubmed/10049273
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