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Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

The pharmacokinetics and bioavailability of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine (cyclic HPMPC) were examined at four doses in 22 patients with human immunodeficiency virus infection. Two groups of six patients received a single dose of cyclic HPMPC at 1.5 or 3.0 mg/k...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Cundy, Kenneth C., Barditch-Crovo, Patricia, Petty, Brent G., Ruby, April, Redpath, Murphy, Jaffe, Howard S., Lietman, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89062/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9925517/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.2.271
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