Mixture-Based Heterocyclic Combinatorial Positional Scanning Libraries: Discovery of Bicyclic Guanidines Having Potent Antifungal Activities against Candida albicans and Cryptococcus neoformans

A mixture-based synthetic combinatorial library of more than 100,000 bicyclic guanidines was generated in a positional scanning format and assayed for activity against Candida albicans. Potent individual bicyclic guanidines were directly identified following the screening of the library. Time-kill c...

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Hauptverfasser: Blondelle, Sylvie E., Crooks, Ema, Ostresh, John M., Houghten, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Chemistry; Biosynthesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89029/
https://ncbi.nlm.nih.gov/pubmed/9869574
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