Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs

Double-stranded RNA (dsRNA) of viral origin triggers two programs of the innate immunity in virus-infected cells. One is intended to decrease the rate of host cell protein synthesis and thus to prevent viral replication. This program is mediated by protein kinase R (PKR) and by RNase L and contribut...

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Bibliographic Details
Main Authors: Iordanov, Mihail S., Wong, John, Bell, John C., Magun, Bruce E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC88780/
https://ncbi.nlm.nih.gov/pubmed/11113181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.1.61-72.2001
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