Downregulation of CIITA Function by Protein Kinase A (PKA)-Mediated Phosphorylation: Mechanism of Prostaglandin E, Cyclic AMP, and PKA Inhibition of Class II Major Histocompatibility Complex Expression in Monocytic Lines

Prostaglandins, pleiotropic immune modulators that induce protein kinase A (PKA), inhibit gamma interferon induction of class II major histocompatibility complex (MHC) genes. We show that phosphorylation of CIITA by PKA accounts for this inhibition. Treatment with prostaglandin E or 8-bromo-cyclic A...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Li, Guoxuan, Harton, Jonathan A., Zhu, Xinsheng, Ting, Jenny P.-Y.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2001
Materias:	Transcriptional Regulation
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11416140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.14.4626-4635.2001
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