A Human Protein with Sequence Similarity to Drosophila Mastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters

Mastermind (Mam) has been implicated as an important positive regulator of the Notch signaling pathway by genetic studies using Drosophila melanogaster. Here we describe a biochemical mechanism of action of Mam within the Notch signaling pathway. Expression of a human sequence related to Drosophila...

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Bibliographic Details
Main Authors: Kitagawa, Motoo, Oyama, Toshinao, Kawashima, Taichi, Yedvobnick, Barry, Kumar, Anumeha, Matsuno, Kenji, Harigaya, Kenichi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC87094/
https://ncbi.nlm.nih.gov/pubmed/11390662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.13.4337-4346.2001
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