Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

SLP-76 is an adapter protein required for T-cell receptor (TCR) signaling. In particular, TCR-induced tyrosine phosphorylation and activation of phospholipase C-γ1 (PLC-γ1), and the resultant TCR-inducible gene expression, depend on SLP-76. Nonetheless, the mechanisms by which SLP-76 mediates PLC-γ1...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Yablonski, Deborah, Kadlecek, Theresa, Weiss, Arthur
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2001
Sujets:	Cell Growth and Development
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87082/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.13.4208-4218.2001
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