Eukaryotic Initiation Factor 4G-Poly(A) Binding Protein Interaction Is Required for Poly(A) Tail-Mediated Stimulation of Picornavirus Internal Ribosome Entry Segment-Driven Translation but Not for X-Mediated Stimulation of Hepatitis C Virus Translation

Efficient translation of most eukaryotic mRNAs results from synergistic cooperation between the 5′ m(7)GpppN cap and the 3′ poly(A) tail. In contrast to such mRNAs, the polyadenylated genomic RNAs of picornaviruses are not capped, and translation is initiated internally, driven by an extensive seque...

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Autors principals: Michel, Yanne M., Borman, Andrew M., Paulous, Sylvie, Kean, Katherine M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC87071/
https://ncbi.nlm.nih.gov/pubmed/11390639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.13.4097-4109.2001
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