Site-Specific Genomic Integration in Mammalian Cells Mediated by Phage φC31 Integrase

We previously established that the phage φC31 integrase, a site-specific recombinase, mediates efficient integration in the human cell environment at attB and attP phage attachment sites on extrachromosomal vectors. We show here that phage attP sites inserted at various locations in human and mouse...

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Detalhes bibliográficos
Main Authors: Thyagarajan, Bhaskar, Olivares, Eric C., Hollis, Roger P., Ginsburg, Daniel S., Calos, Michele P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC87055/
https://ncbi.nlm.nih.gov/pubmed/11359900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.3926-3934.2001
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