Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA

Selenocysteine (Sec) tRNA (tRNA([Ser]Sec)) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein biosynthesis of overexpressing either the wild type or a mutant tRNA([Ser]Sec) lacking the modified base, isop...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammad A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., Hill, Kristina E., Combs, Gerald F., Feigenbaum, Lionel, Mansur, David B., Burk, Raymond F., Berry, Marla J., Diamond, Alan M., Lee, Byeong Jae, Gladyshev, Vadim N., Hatfield, Dolph L.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2001
Fag:	Gene Expression
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87048/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11340175/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.11.3840-3852.2001
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