Selective Inhibition of Selenocysteine tRNA Maturation and Selenoprotein Synthesis in Transgenic Mice Expressing Isopentenyladenosine-Deficient Selenocysteine tRNA

Selenocysteine (Sec) tRNA (tRNA([Ser]Sec)) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein biosynthesis of overexpressing either the wild type or a mutant tRNA([Ser]Sec) lacking the modified base, isop...

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Bibliografski detalji
Glavni autori: Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammad A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., Hill, Kristina E., Combs, Gerald F., Feigenbaum, Lionel, Mansur, David B., Burk, Raymond F., Berry, Marla J., Diamond, Alan M., Lee, Byeong Jae, Gladyshev, Vadim N., Hatfield, Dolph L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Gene Expression
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC87048/
https://ncbi.nlm.nih.gov/pubmed/11340175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3840-3852.2001
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