Cisplatin Induces the Proapoptotic Conformation of Bak in a ΔMEKK1-Dependent Manner

In a panel of four human melanoma cell lines, equitoxic doses of cisplatin induced the proapoptotic conformation of the Bcl-2 family protein Bak prior to the execution phase of apoptosis. Because cisplatin-induced modulation of the related Bax protein was seen in only one cell line, a degree of spec...

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Detalhes bibliográficos
Main Authors: Mandic, Aleksandra, Viktorsson, Kristina, Molin, Magnus, Akusjärvi, Göran, Eguchi, Hidetaka, Hayashi, Shin-Ichi, Toi, Masakazu, Hansson, Johan, Linder, Stig, Shoshan, Maria C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86999/
https://ncbi.nlm.nih.gov/pubmed/11340162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3684-3691.2001
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