The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang

The major pathway in mammalian cells for repairing DNA double-strand breaks (DSB) is via nonhomologous end joining. Five components function in this pathway, of which three (Ku70, Ku80, and the DNA-dependent protein kinase catalytic subunit [DNA-PKcs]) constitute a complex termed DNA-dependent prote...

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Bibliographic Details
Main Authors: Goytisolo, Fermín A., Samper, Enrique, Edmonson, Scott, Taccioli, Guillermo E., Blasco, María A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86989/
https://ncbi.nlm.nih.gov/pubmed/11340158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.11.3642-3651.2001
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