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Role of NF-Y in In Vivo Regulation of the γ-Globin Gene

The duplicated CCAAT box is required for γ gene expression. We report here that the transcriptional factor NF-Y is recruited to the duplicated CCAAT box in vivo. A mutation of the duplicated CCAAT box that severely disrupts the NF-Y binding also reduces the accessibility level of the γ gene promoter...

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Detalhes bibliográficos
Main Authors: Duan, Zhijun, Stamatoyannopoulos, George, Li, Qiliang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86936/
https://ncbi.nlm.nih.gov/pubmed/11287613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.9.3083-3095.2001
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