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Dimerization of Sterol Regulatory Element-Binding Protein 2 via the Helix-Loop-Helix-Leucine Zipper Domain Is a Prerequisite for Its Nuclear Localization Mediated by Importin β

The sterol regulatory element-binding protein 2 (SREBP-2), a transcription factor of the basic helix-loop-helix-leucine zipper (bHLH-Zip) family, is synthesized in the form of a membrane-attached precursor molecule. When cells are deprived of sterols, a two-step proteolytic processing releases the t...

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Bibliografske podrobnosti
Main Authors: Nagoshi, Emi, Yoneda, Yoshihiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC86908/
https://ncbi.nlm.nih.gov/pubmed/11283257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.8.2779-2789.2001
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