Essential Role of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in Adipocyte Differentiation

To investigate the role of insulin receptor substrate 1 (IRS-1) and IRS-2, the two ubiquitously expressed IRS proteins, in adipocyte differentiation, we established embryonic fibroblast cells with four different genotypes, i.e., wild-type, IRS-1 deficient (IRS-1(−/−)), IRS-2 deficient (IRS-2(−/−)),...

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Bibliographische Detailangaben
Hauptverfasser: Miki, Hiroshi, Yamauchi, Toshimasa, Suzuki, Ryo, Komeda, Kajuro, Tsuchida, Atsuko, Kubota, Naoto, Terauchi, Yasuo, Kamon, Junji, Kaburagi, Yasushi, Matsui, Junji, Akanuma, Yasuo, Nagai, Ryozo, Kimura, Satoshi, Tobe, Kazuyuki, Kadowaki, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86884/
https://ncbi.nlm.nih.gov/pubmed/11259600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.7.2521-2532.2001
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