Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase Cγ1 Phosphorylation

In this study, we investigate the role of the receptor-like protein tyrosine phosphatase CD148 in T-cell activation. Overexpression of CD148 in the Jurkat T-cell line inhibited activation of the transcription factor nuclear factor of activated T cells following T-cell receptor (TCR) stimulation but...

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Bibliographic Details
Main Authors: Baker, Jeanne E., Majeti, Ravindra, Tangye, Stuart G., Weiss, Arthur
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC86872/
https://ncbi.nlm.nih.gov/pubmed/11259588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.7.2393-2403.2001
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