HIRA, the Human Homologue of Yeast Hir1p and Hir2p, Is a Novel Cyclin-cdk2 Substrate Whose Expression Blocks S-Phase Progression

Substrates of cyclin-cdk2 kinases contain two distinct primary sequence motifs: a cyclin-binding RXL motif and one or more phosphoacceptor sites (consensus S/TPXK/R or S/TP). To identify novel cyclin-cdk2 substrates, we searched the database for proteins containing both of these motifs. One such pro...

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Detalhes bibliográficos
Main Authors: Hall, Caitlin, Nelson, David M., Ye, Xiaofen, Baker, Kayla, DeCaprio, James A., Seeholzer, Steven, Lipinski, Marc, Adams, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86753/
https://ncbi.nlm.nih.gov/pubmed/11238922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1854-1865.2001
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