Cardiomyopathy in Irx4-Deficient Mice Is Preceded by Abnormal Ventricular Gene Expression

To define the role of Irx4, a member of the Iroquois family of homeobox transcription factors in mammalian heart development and function, we disrupted the murine Irx4 gene. Cardiac morphology in Irx4-deficient mice (designated Irx4(Δex2/Δex2)) was normal during embryogenesis and in early postnatal...

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Autores principales: Bruneau, Benoit G., Bao, Zheng-Zheng, Fatkin, Diane, Xavier-Neto, Jose, Georgakopoulos, Dimitrios, Maguire, Colin T., Berul, Charles I., Kass, David A., Kuroski-de Bold, Mercedes L., de Bold, Adolfo J., Conner, David A., Rosenthal, Nadia, Cepko, Constance L., Seidman, Christine E., Seidman, J. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC86719/
https://ncbi.nlm.nih.gov/pubmed/11238910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.5.1730-1736.2001
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