Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

In Saccharomyces cerevisiae, rapid degradation of nonsense-containing mRNAs requires the decapping enzyme Dcp1p, the 5′-to-3′ exoribonuclease Xrn1p, and the three nonsense-mediated mRNA decay (NMD) factors, Upf1p, Nmd2p, and Upf3p. To identify specific functions for the NMD factors, we analyzed the...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	He, Feng, Jacobson, Allan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Gene Expression
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86698/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238889/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.5.1515-1530.2001
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