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The NH(2)-Terminal Coiled-Coil Domain and Tyrosine 177 Play Important Roles in Induction of a Myeloproliferative Disease in Mice by Bcr-Abl

Bcr-Abl, a fusion protein generated by t(9;22)(q34;q11) translocation, plays a critical role in the pathogenesis of chronic myelogenous leukemia (CML). It has been shown that Bcr-Abl contains multiple functional domains and motifs and can disrupt regulation of many signaling pathways and cellular fu...

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Udgivet i:Mol Cell Biol
Principais autores: Zhang, Xiaowu, Subrahmanyam, Ramesh, Wong, Ray, Gross, Alec W., Ren, Ruibao
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2001
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86675/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11154271/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.3.840-853.2001
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