The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells

The cap-binding translation initiation factor eukaryotic initiation factor 4E (eIF4E) is phosphorylated in vivo at Ser209 in response to a variety of stimuli. In this paper, we show that the mitogen-activated protein kinase (MAPK) signal-integrating kinase Mnk2 phosphorylates eIF4E at this residue....

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Publicat a:	Mol Cell Biol
Autors principals:	Scheper, Gert C., Morrice, Nick A., Kleijn, Miranda, Proud, Christopher G.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2001
Matèries:	Cell Growth and Development
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11154262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.3.743-754.2001
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