The Mechanism of Mammalian Gene Replacement Is Consistent with the Formation of Long Regions of Heteroduplex DNA Associated with Two Crossing-Over Events

In this study, the mechanism of mammalian gene replacement was investigated. The system is based on detecting homologous recombination between transferred vector DNA and the haploid, chromosomal immunoglobulin μ-δ region in a murine hybridoma cell line. The backbone of the gene replacement vector (p...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Li, Julang, Read, Leah R., Baker, Mark D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2001
Gaiak:
DNA Dynamics and Chromosome Structure
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC86609/
https://ncbi.nlm.nih.gov/pubmed/11134338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.501-510.2001
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