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Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury

Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the...

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Published in:Mol Cell Biol
Main Authors: Leu, Julia I., Crissey, Mary Ann S., Leu, James P., Ciliberto, Gennaro, Taub, Rebecca
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2001
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86585/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134330/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.2.414-424.2001
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