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Recombinogenic Flap Ligation Pathway for Intrinsic Repair of Topoisomerase IB-Induced Double-Strand Breaks

Topoisomerase IB catalyzes recombinogenic DNA strand transfer reactions in vitro and in vivo. Here we characterize a new pathway of topoisomerase-mediated DNA ligation in vitro (flap ligation) in which vaccinia virus topoisomerase bound to a blunt-end DNA joins the covalently held strand to a 5′ res...

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Udgivet i:Mol Cell Biol
Principais autores: Cheng, Chonghui, Shuman, Stewart
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86416/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11027276/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.21.8059-8068.2000
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