Recombinogenic Flap Ligation Pathway for Intrinsic Repair of Topoisomerase IB-Induced Double-Strand Breaks

Topoisomerase IB catalyzes recombinogenic DNA strand transfer reactions in vitro and in vivo. Here we characterize a new pathway of topoisomerase-mediated DNA ligation in vitro (flap ligation) in which vaccinia virus topoisomerase bound to a blunt-end DNA joins the covalently held strand to a 5′ res...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Cheng, Chonghui, Shuman, Stewart
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2000
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86416/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11027276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.21.8059-8068.2000
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