SAF-Box, a Conserved Protein Domain That Specifically Recognizes Scaffold Attachment Region DNA

Míreanna Comhchosúla

• The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.
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• A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis
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• Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA.
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• A bipartite sequence element associated with matrix/scaffold attachment regions.
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• Characterization of SAF-A, a novel nuclear DNA binding protein from HeLa cells with high affinity for nuclear matrix/scaffold attachment DNA elements.
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