Activation of V(D)J Recombination Induces the Formation of Interlocus Joints and Hybrid Joints in scid Pre-B-Cell Lines

V(D)J recombination is the mechanism by which antigen receptor genes are assembled. The site-specific cleavage mediated by RAG1 and RAG2 proteins generates two types of double-strand DNA breaks: blunt signal ends and covalently sealed hairpin coding ends. Although these DNA breaks are mainly resolve...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Lew, Sandra, Franco, Daniel, Chang, Yung
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2000
Témata:	DNA Dynamics and Chromosome Structure
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86270/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10982833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.19.7170-7177.2000
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