Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

We used an allelogenic Cre/loxP gene targeting strategy in mice to determine the role of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in hepatic energy metabolism. Mice that lack this enzyme die within 3 days of birth, while mice with at least a 90% global reduction of PEPCK, or a liver-speci...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	She, Pengxiang, Shiota, Masakazu, Shelton, Kathy D., Chalkley, Roger, Postic, Catherine, Magnuson, Mark A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2000
Témata:	Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86125/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10938127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.17.6508-6517.2000
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Phosphoenolpyruvate Carboxykinase Is Necessary for the Integration of Hepatic Energy Metabolism

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