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TrkA Immunoglobulin-Like Ligand Binding Domains Inhibit Spontaneous Activation of the Receptor

The extracellular region of the nerve growth factor (NGF) receptor, TrkA, contains two immunoglobulin (Ig)-like domains that are required for specific ligand binding. We have investigated the possible role of these two Ig-like domains in receptor dimerization and activation by using different mutant...

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Autori principali: Arevalo, Juan C., Conde, Blanca, Hempstead, Barbara L., Chao, Moses V., Martin-Zanca, Dionisio, Perez, Pilar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC86068/
https://ncbi.nlm.nih.gov/pubmed/10913174
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