Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma

Somatic mutations at Thr-58 of c-Myc have been detected in Burkitt's lymphoma (BL) tumors and have been shown to affect the transforming potential of the Myc oncoprotein. In addition, the N-terminal domain of c-Myc has been shown to interact with microtubules in vivo, and the binding of c-Myc t...

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Bibliographic Details
Main Authors: Niklinski, Jacek, Claassen, Gisela, Meyers, Cheryl, Gregory, Mark A., Allegra, Carmen J., Kaye, Frederic J., Hann, Stephen R., Zajac-Kaye, Maria
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC85977/
https://ncbi.nlm.nih.gov/pubmed/10866684
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