Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation

Interleukin-2 (IL-2) activates several different families of tyrosine kinases, but precisely how these kinases interact is not completely understood. We therefore investigated the functional relationships among Jak3, Lck, and Syk in IL-2 signaling. We first observed that in the absence of Jak3, both...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhou, Yong-Jie, Magnuson, Kelly S., Cheng, Tammy P., Gadina, Massimo, Frucht, David M., Galon, Jerome, Candotti, Fabio, Geahlen, Robert L., Changelian, Paul S., O'Shea, John J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC85804/
https://ncbi.nlm.nih.gov/pubmed/10825200
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