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p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/or gadd45 Genes

Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the pathway for repair of UV-induced DNA damage. The global genomic repair (GGR) subpathway of NER, but not transcription-coupled repair (TCR), is mainly affected by p53 loss or inactivation. We have...

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Published in:Mol Cell Biol
Main Authors: Smith, Martin L., Ford, James M., Hollander, M. Christine, Bortnick, Rachel A., Amundson, Sally A., Seo, Young R., Deng, Chu-Xia, Hanawalt, Philip C., Fornace, Albert J.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2000
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10779360/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.10.3705-3714.2000
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