Nedd8 Modification of Cul-1 Activates SCF(β(TrCP))-Dependent Ubiquitination of IκBα

Regulation of NF-κB occurs through phosphorylation-dependent ubiquitination of IκBα, which is degraded by the 26S proteasome. Recent studies have shown that ubiquitination of IκBα is carried out by a ubiquitin-ligase enzyme complex called SCF(β(TrCP)). Here we show that Nedd8 modification of the Cul...

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Detaylı Bibliyografya
Yayımlandı:	Mol Cell Biol
Asıl Yazarlar:	Read, Margaret A., Brownell, James E., Gladysheva, Tatiana B., Hottelet, Maria, Parent, Lana A., Coggins, Michael B., Pierce, Jacqueline W., Podust, Vladimir N., Luo, Rong-Shu, Chau, Vincent, Palombella, Vito J.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis 2000
Konular:	Cell Growth and Development
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85397/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10713156/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.7.2326-2333.2000
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Nedd8 Modification of Cul-1 Activates SCF(β(TrCP))-Dependent Ubiquitination of IκBα

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