Nedd8 Modification of Cul-1 Activates SCF(β(TrCP))-Dependent Ubiquitination of IκBα

Regulation of NF-κB occurs through phosphorylation-dependent ubiquitination of IκBα, which is degraded by the 26S proteasome. Recent studies have shown that ubiquitination of IκBα is carried out by a ubiquitin-ligase enzyme complex called SCF(β(TrCP)). Here we show that Nedd8 modification of the Cul...

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Autors principals: Read, Margaret A., Brownell, James E., Gladysheva, Tatiana B., Hottelet, Maria, Parent, Lana A., Coggins, Michael B., Pierce, Jacqueline W., Podust, Vladimir N., Luo, Rong-Shu, Chau, Vincent, Palombella, Vito J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC85397/
https://ncbi.nlm.nih.gov/pubmed/10713156
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