Bag1 Functions In Vivo as a Negative Regulator of Hsp70 Chaperone Activity

Studies on the Hsp70 chaperone machine in eukaryotes have shown that Hsp70 and Hsp40/Hdj1 family proteins are sufficient to prevent protein misfolding and aggregation and to promote refolding of denatured polypeptides. Additional protein cofactors include Hip and Bag1, identified in protein interact...

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Autores principales: Nollen, Ellen A. A., Brunsting, Jeanette F., Song, Jaewhan, Kampinga, Harm H., Morimoto, Richard I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC85225/
https://ncbi.nlm.nih.gov/pubmed/10629065
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