Targeted Deletion of the tub Mouse Obesity Gene Reveals that tubby Is a Loss-of-Function Mutation

The mouse tubby phenotype is characterized by maturity-onset obesity accompanied by retinal and cochlear degeneration. A positional cloning effort to find the gene responsible for this phenotype led to the identification of tub, a member of a novel gene family of unknown function. A splice defect mu...

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Detalhes bibliográficos
Main Authors: Stubdal, Hilde, Lynch, Catherine A., Moriarty, Ann, Fang, Qing, Chickering, Troy, Deeds, James D., Fairchild-Huntress, Victoria, Charlat, Olga, Dunmore, Judy H., Kleyn, Patrick, Huszar, Dennis, Kapeller, Rosana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85204/
https://ncbi.nlm.nih.gov/pubmed/10629044
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